"What If" was the second single from Creed's 1999 album Human Clay, and was the sixth consecutive #1 hit for the band.

In this song, Scott Stapp sings about those who oppress the band with their words and hatred. He seems to be referring to the media and critics who lashed out at Creed, and asks what they would do if faced with a similar situation.

The song was used in the 2000 movie Scream 3, for which Creed helped to produce the soundtrack. The music video portrayed Creed band members being killed by the infamous Ghostface character from the Scream films, and features actor David Arquette.

According to guitarist Mark Tremonti, the intro was inspired by both "Paint It Black" from The Rolling Stones and the The Legend of Zelda series of Nintendo video games.

In 2006, Chris Daughtry performed this on American Idol.

"What If" is a single by actress Kate Winslet, released in November 2001.

The song is taken from the 2001 animated film Christmas Carol: The Movie which is based on the Charles Dickens classic novel. Winslet provided the voice of Belle in the film, which also stars Nicholas Cage, Jane Horrocks and Simon Callow.

"What If" is a ballad that follows the film's theme, and was the first and only song to be released from the official movie soundtrack. It was written by Julian Knott and produced by Steve Mac, who has worked with Westlife, Boyzone and 5ive. The music video, which was directed by Chris Horton, shows Winslet walking around an old Victorian house, along with clips from the film.

News that Winslet was secretly recording the one-off single to vie for the 2001 UK Christmas number one spot was reported in the The Daily Mirror newspaper. In the event the song entered the UK singles chart at number 6, and was beaten to the Christmas top spot by Robbie Williams and Nicole Kidman's version of "Somethin' Stupid". "What If" debuted at number 1 on the Irish singles chart on 8 December 2001, toppling Irish television puppet Dustin's version of "Sweet Caroline". It remained at number 1 for four weeks. At Winslet's request, the proceeds from the single were given to the NSPCC and Sargent Cancer Care For Children.

In 2004, a dance remake of the song was released by Ronny V featuring Nanda.

"What If" written by Diane Warren, was a 1997 promotional single by country music artist Reba McEntire. This single was released commercially to benefit the Salvation Army with all proceeds being donated to their service. The song was performed by Reba at the Dallas Cowboys Halftime Game on Thanksgiving Day, 1997. The song was an inspirational song and also a boost to help benefit the cause of the Salvation Army.