Out of Jimmy's Head is Cartoon Network's first live-action/animated television series. It is based on the live-action/animated telefilm Re-Animated that aired on December 8, 2006. The series premiered on Cartoon Network on September 14, 2007 to coincide the release of Re-Animated on DVD. The premiere was advertised to air at 7:00 PM of that day, but the show actually aired several times earlier that day (7:00 AM, 2:30 PM and 4:30 PM). The show was affected by the 2007 Writers Guild of America strike. Out of Jimmy's Head is the only show on Cartoon Network that was affected by that strike.

Although promoted to be the "first live action/animated series on Cartoon Network," the show, in fact, is not the first. The first was, in fact, Space Ghost Coast to Coast, which ran from 1994 to 2004; this was Cartoon Network's first original series overall, as well. In addition, Cartoon Network aired Big Bag, a collaboration of both live action and animation, co-produced by The Jim Henson Company and Cartoon Network. It was aired June 2, 1996 and lasted until September of 1998.

The show is produced by Brookwell McNamara Entertainment, who has produced other kid's television such as Even Stevens and That's So Raven.