Nothing Safe: Best of the Box is an album by the grunge band Alice in Chains. It was released on June 29, 1999 on Columbia Records.

The album is the first of Alice in Chains's best-of albums, and also served as a sampler for their Music Bank box set. The album contains songs from previous albums Facelift, Alice in Chains, Sap, Dirt, and Jar of Flies, as well as the previously unreleased track "Get Born Again".

Despite being titled "Best of the Box", the demo version of "We Die Young" that appears here is not included on the Music Bank box set, and is exclusive to this collection.