Lithium orotate, is a lithium salt of pyrimidinecarboxylic acid and lithium. It is available as the monohydrate, LiC 5 H 3 N 2 O 4 ·H 2 O .

Lithium orotate is generally marketed as a dietary supplement used in small doses to treat conditions including stress, manic depression, alcoholism, ADHD and ADD, aggression, PTSD, Alzheimer's and to improve memory. It has controversially been promoted as an alternative to lithium carbonate. In this compound, lithium is coupled with an orotate ion, rather than to a carbonate or other ion. Lithium orotate is sold under a wide variety of brand names and is available at some drugstores and health food stores.

Although a few psychiatrists prescribe lithium orotate to their patients, it is most often naturopaths and other health practictioners who recommend this mineral to their patients.